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Wysłany: Śro 10:16, 22 Lut 2006
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Wysłany: Nie 23:44, 08 Sty 2006
Temat postu: What is phentermine?
Phentermine (marketed as adipex) is one of two drugs in the
fen-phen
anti-
obesity
medication, the other being
fenfluramine
or dexfenfluramine. fenfluramine was withdrawn from the
u.s.
market in
1997
after reports of valvular heart disease and
pulmonary hypertension
.
phentermine is still available by itself in most countries, including the u.s. internationally, phentermine is a schedule iv drug under the
convention on psychotropic substances
in the
united states
, it is classified as a
schedule iv
controlled substance
under the
controlled substances act
.
phentermine, as many other prescription drugs, works with
neurotransmitters
in the brain. it is a centrally-acting
stimulant
chemically related to the
amphetamines
. it stimulates
neuron
bundles to release a particular group of neurotransmitters known as
catecholamines
; these include
dopamine
,
epinephrine
(also known as adrenalin), and
norepinephrine
(noradrenalin). this is the same mechanism of action as other stimulant appetite suppresants such as
sibutramine
and
dextroamphetamine
.
the neurotransmitters signal a
fight-or-flight response
in your body which, in turn, puts a halt to the hunger signal. as a result, you lose your appetite because your brain doesn’t receive the hunger message. this is perhaps because of phentermine’s effects on
leptin
levels in the brain. it is theorized that phentermine can raise levels of leptin which signal
satiety
. it is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as
neuropeptide y
. this chemical initiates eating, decreases energy expenditure, and increases fat storage.
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